| 摘要 |
PROBLEM TO BE SOLVED: To provide a new compound of a phosphonic acid diester derivative as an active ingredient of a medicine. SOLUTION: An ACAT-1 inhibitor which is the medicine comprises the phosphonic acid diester derivative represented by the formula (wherein, R<SB>1</SB>, R<SB>2</SB>, R<SB>3</SB>and R<SB>4</SB>are each the same or different and denote each a hydrogen atom, a halogen atom, a lower alkyl group or a lower alkoxy group; R<SB>5</SB>denotes a phenyl group having 1-3 substituents selected from the group consisting of a lower alkyl group, a halogen-substituted lower alkyl group, a lower alkoxy group, a halogen-substituted lower alkoxy group, a phenoxy group, a benzyloxy group, a hydroxy group, a halogen atom, a nitro group, a lower alkylthio group, a dilower alkylamino group, a lower alkanoylamino group, a pyrrolidinyl group and phenyl group on the phenyl ring, a benzodioxolanyl group or the like, with the proviso that R<SB>5</SB>should not be a monolower alkoxyphenyl group; and R<SB>6</SB>denotes a lower alkyl group) as the active ingredient. COPYRIGHT: (C)2004,JPO
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