发明名称 |
Compositions and methods related to TIM-3, a Th1-specific cell surface molecule |
摘要 |
The present invention provides compositions and methods useful for promoting or reducing T-cell trafficking to a target tissue. Also provided are compositions and methods useful for promoting or inhibiting antigen-presenting cell (APC) activation. The invention is related to discovery of functional characteristics of TIM-3, a molecule that is preferentially expressed on the surface of Th1 cells. The methods are useful for treating disorders including cancer, infectious disease, allergy, asthma, and autoimmune disease.
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申请公布号 |
US2004005322(A1) |
申请公布日期 |
2004.01.08 |
申请号 |
US20030354447 |
申请日期 |
2003.01.30 |
申请人 |
KUCHROO VIJAY K.;MONNEY LAURENT;GAGLIA JASON L.;GREENFIELD EDWARD A.;FREEMAN GORDON J.;WALDNER HANSPETER |
发明人 |
KUCHROO VIJAY K.;MONNEY LAURENT;GAGLIA JASON L.;GREENFIELD EDWARD A.;FREEMAN GORDON J.;WALDNER HANSPETER |
分类号 |
C12N15/09;A61K38/00;A61K39/395;A61K45/00;A61P31/04;A61P35/00;A61P43/00;C07K16/28;C12N5/06;C12N15/00;(IPC1-7):A61K39/395 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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