FLUORINATED CHLORIN AND BACTERIOCHLORIN PHOTOSENSITIZERS FORPHOTODYNAMIC THERAPY

摘要

Provided herein are tetrapyrrole compounds containing a fluorinated substituent for detection, diagnosis and treatment of target tissues or targ et compositions, including hyperproliferative tissues such as tumors, using photodynamic methods. In particular, photosensitizer compounds that collect in hyperproliferative tissue are provided. In another embodiment, compounds tha t absorb light at a wavelength of from about 700 to about 850 nm are provided. In a further embodiment, compounds that are detectable by magnetic resonance imaging are provided.