| 摘要 |
Provided herein are methods of detecting a cancer or a pre-cancer in a subject. In these methods the amount of antibody or antibody fragment bound to an epitope of a S2-6 DNA binding protein or, alternatively, the amount of S2-6 mRNA expression in a first tissue sample from the subject suspected of being cancerous or precancerous is compared with the levels of binding or expression, respectively, in a second sample taken from healthy tissue as the same type as the first sample. No binding or a lesser binding of the antibody or antibody fragment, or, alternatively, no S2-6 mRNA expression or lesser expression by the first sample as compared to that of the second sample is indicative of a cancer or a pre-cancer in the subject. Also provided are methods of treating a cancer or a pre-cancer in a subject. Kits are provided to perform the methods disclosed herein.
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