COATED SUSTAINED RELEASE TABLETS OF A HYGROSCOPIC COMPOUND FOR ONCE-A-DAY THERAPY

摘要

The present invention provides coated sustained release tablets of a hygroscopic compound for once-a-day therapy, said tablets having a moderate weight and volume and comprising (a) a core comprising the hygroscopic compound and pharmaceutically acceptable excipients, (b) a first coating layer comprising a polymer selected from the group consisting of water-insoluble polymers, pH dependent polymers or a mixture thereof, and (c) a second coating layer comprising a water-insoluble polymer.