HOLLOW NANOPARTICLE HAVING MODIFIED CYSTEINE RESIDUE AND DRUG WITH THE USE THEREOF

摘要

A hollow nanoparticle which comprises a protein (for example, hepatitis B virus surface antigen protein) having a function of recognizing a specific cell such as a liver cell and being capable of forming a particle, wherein a cysteine residue of the protein is replaced by another amino acid. Thus, it is possible to provide a nanoparticle by which a substance can be specifically introduced into a target cell or tissue and which has a stabilized particle structure and enables efficient introduction of the substance, and a drug with the use thereof.