发明名称 |
ANTAGONISTS OF MEGALIN OR CUBILIN FOR USE IN PREVENTING ORGAN DAMAGE INDUCED BY THERAPEUTIC AGENTS |
摘要 |
The invention relates to agents for the prevention of organ damage, in particular of the kidneys and the inner ear, induced by the administration of aminoglycosides. Agents according to the invention are all substances which are megalin and/or cubilin antagonists (inhibitors). In particular, these are molecules (compounds) having polybasic structures which bind to megalin and inhibit the binding of aminoglyco-sides and related substances. |
申请公布号 |
WO03080103(A8) |
申请公布日期 |
2004.01.08 |
申请号 |
WO2002IB01393 |
申请日期 |
2002.04.25 |
申请人 |
MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN;WILLNOW, THOMAS |
发明人 |
WILLNOW, THOMAS |
分类号 |
A61K31/19;A61K31/519;A61K31/535;A61K31/7036;A61K31/7048;A61K38/16;A61K38/17;A61K38/57;A61K45/06;A61P13/12;(IPC1-7):A61K38/12 |
主分类号 |
A61K31/19 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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