MARKED PEPTIDES HAVING AFFINITY FOR A PHOSPHOLIPID AND USES

摘要

The invention concerns a peptide marked by Fluor 18 for specific identification of lipid vectors. The inventive peptide comprises the following peptide sequence (PI): J1-J2-J3-J4-J5-J6-Z7-U8-J9-J10-U11-Arg-J13-J14-U15-Lys-Gly-X18-Gly-Thr-J21-Glu-J23-J24-U25-J26-J27-J28-U29-J30-J31-Arg-J33-J34-J35-J36-B37-J38-J39-U40-J41-J42-J43-U44-J45-J46-J47-J48-J49-Arg-J51-U52-J53-J54-Asp-U56-Lys-Ser-Z59-Leu-J61-J62-J63-J64-Z65-J66-J67-U68-J69-J70-J71-U72-J73-J74-J75 (PI) wherein the amino acids J are selected independently of one another among Arg, Asn, Asp, Cys, Gln, Glu, Gly, His, Lys, Orn, Pro, Ser, Thr and Tyr; the amino acids U are selected independently of one another among Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr et Val; the amino acid X<18> is selected independently of the other amino acids of the sequence among Ala, Asn, Cys, Gln, Gly, His, Ile, Leu, Met, Phe, Ser, Thr, Trp, Tyr et Val; the amino acid B<37> is selected independently of the other amino acids of the sequence Arg, Ala, Cys, Gly, Ile, Leu, Met, Phe, Trp, Tyr et Val; the amino acid< >Z<7> is selected independently of the other amino acids among Asp or Glu; the amino acids Z<59> and Z<65> are selected among Glu, Asp, Lys or Arg; the exponents of residues J, Z, U, X and B represent the position of the amino acids in said sequence.