发明名称 |
METHODS AND COMPOSITIONS FOR MANIPULATING THE GUIDED NAVIGATION OF ENDOTHELIAL TUBES DURING ANGIOGENESIS |
摘要 |
Methods and compositions for manipulating the directed navigation of physiological tracking tubular structures are provided. A novel cell-bound receptor, roundabout-4 (Robo-4), is described. The Robo-4 receptor shows sequence and structural similarity to members of the roundabout family of receptors. Also, the Robo-4 receptor binds Slit ligand, a known receptor of the roundabout receptors. Polynucleotides and polypeptides of the Robo-4 receptor are described. |
申请公布号 |
WO2004003163(A2) |
申请公布日期 |
2004.01.08 |
申请号 |
WO2003US20508 |
申请日期 |
2003.06.27 |
申请人 |
UNIVERSITY OF UTAH RESEARCH FOUNDATION;LI, DEAN, Y.;PARK, KYE, WON |
发明人 |
LI, DEAN, Y.;PARK, KYE, WON |
分类号 |
A61K38/00;C07K14/47;C07K14/705 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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