BICYCLIC LACTAM DERIVATIVES AS INHIBITORS OF MATRIX METALLOPROTEINASES AND/OR TNF-alpha CONVERTING ENZYME (TACE)

摘要

The present application describes novel bicyclic lactam derivatives of formula (I) or pharmaceutically acceptable salt forms th ereof, wherein A, B, C, D, R<1>, and R<2> are defined in the present specification, which are useful as metalloprotease, TNF-alpha, and/or aggrecanase inhibitors.