METHOD FOR IDENTIFYING STAT AFFECTING AGENTS

摘要

The present invention relates to a method for identifying an agonist and an antagonist of a cytoplasmic estrogen receptor (ER). The present invention also relates to determining if an agent affects the ability of a cytoplasmic agonist-bound estrogen receptor (ER) to mediate phosphorylation of one or more Signal Transducer and Activator of Transcription (STAT) proteins. The present invention also relates to the use of a cytoplasmic ER agonist, antagonist or an agent that affects the ability of a cytoplasmic agonist-bound ER to mediate phosphorylation of one or more STAT proteins, in the treatment of prophylaxis of a disease caused by abnormal phosphorylation of one of more STAT proteins. For example, the disease may be a cardiovascular disease, osteoporosis, an immune disease, a psychological disease such as memory loss or depression, oncogenesis, tumour progression, inflammation or diabetes.