SKIN EXTERNAL AGENT CHARACTERIZED WITH EPIDERMIS BASEMENT MEMBRANE CARE, EPIDERMIS BASEMENT MEMBRANE STRUCTURE FORMATION-ACCELERATING AGENT

摘要

PURPOSE: A skin external agent characterized with epidermis basement membrane care as an epidermis basement membrane structure formation-accelerating agent is provided, thereby accelerating the repair and re-formation of skin basement membrane structure, and achieving the sufficient formation of the basement membrane in the production of an artificial skin. CONSTITUTION: The epidermis basement membrane structure formation-accelerating agent consists of a serine protease inhibitor and optionally an extracellular matrix protein production-accelerating agent as active ingredients. A method for producing the artificial skin having sufficiently formed basement membrane comprises a step of culturing an artificial skin-forming medium, characterized by adding one or more serine protease inhibitors to the artificial skin-forming medium, and further adding one or more extracellular matrix protein production accelerators to the artificial skin-forming medium.