| 摘要 |
PURPOSE: Provided are 2,2-Dimethyl-3-hydroxy-4-alkoxy-6-alkyl amino benzopyran derivatives and a method for manufacturing the same in higher yield using parallel synthesis on the solid-phase. The derivatives have excellent lipid peroxidation and are thus used for prevention and treatment of diseases associated with lipid peroxidation. CONSTITUTION: 2,2-Dimethyl-3-hydroxy-4-alkoxy-6-alkyl amino benzopyran derivatives are characteristically represented by the formula(4a), wherein R¬1a represents an aryl group, a benzyl group or a substituted benzyl group, a naphthylmethyl group, or a penethyl group; and R¬2 represents a C1-C10 alkyl group, benzyl group or a substituted benzyl group, wherein a substituent is selected from a halogen atom, a nitro group, a C1-C10 alkyl group, C1-C10 alkoxy group and C1-C10 haloalkyl group.
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