发明名称 |
Membrane-bound dominant negative Flk-1 receptor for vascular endothelial growth factor |
摘要 |
<p>The present invention relates to the use of ligands for the Flk-1 receptor for the modulation of angiogenesis and vasculogenesis. The invention is based, in part, on the demonstration that Flk-1 tyrosine kinase receptor expression is associated with endothelial cells and the identification of vascular endothelial growth factor (VEGF) as the high affinity ligand of Flk-1. These results indicate a major role for Flk-1 in the signaling system during vasculogenesis and angiogenesis. Engineering of host cells that express Flk-1 and the uses of expressed Flk-1 to evaluate and screen for drugs and analogs of VEGF involved in Flk-1 modulation by either agonist or antagonist activities is described. The invention also relates to the use of Flk-1 ligands, including VEGF agonists and antagonists, in the treatment of disorders, including cancer, by modulating vasculogenesis and angiogenesis.</p> |
申请公布号 |
EP1378570(A1) |
申请公布日期 |
2004.01.07 |
申请号 |
EP20030009148 |
申请日期 |
1993.11.15 |
申请人 |
MAX-PLANCK-GESELLSCHAFT ZUR FOERDERUNGDER WISSENSCHAFTEN E.V. |
发明人 |
ULLRICH, AXEL, PROF. DR.;RISAU, WERNER, PROF. DR.;MILLAUER, BIRGIT, PH.D. |
分类号 |
G01N33/53;A61K31/235;A61K31/275;A61K31/277;A61K31/38;A61K31/40;A61K31/415;A61K31/42;A61K31/495;A61K31/502;A61K31/505;A61K31/517;A61K31/535;A61K38/00;A61K38/16;A61K39/395;A61P35/00;C07C229/60;C07C255/36;C07C255/40;C07C255/41;C07C255/66;C07C317/46;C07C327/44;C07D209/18;C07D239/93;C07D239/94;C07D241/42;C07D241/44;C07D487/04;C07D498/04;C07H21/04;C07K14/71;C07K16/28;C12N5/10;C12N15/09;C12N15/12;C12P21/02;C12P21/08;C12R1/91;G01N33/50;G01N33/577;G01N33/68;(IPC1-7):C12N15/12;G01N33/567;C12N15/86;C12Q1/68;C12N15/62 |
主分类号 |
G01N33/53 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|