| 摘要 |
PURPOSE: Provided is a mixed extract of Radix Salviae miltiorrhizae and Rhizoma Cnidii which has inhibition effect on apoptotic cardiac cell death. Therefore, the extract is clinically useful. CONSTITUTION: A mixed extract of Radix Salviae miltiorrhizae and Rhizoma Cnidii characteristically inhibits apoptotic cardiac cell death by increasing the cell viability, reducing the fraction of DNA and PARP, decreasing the activity of Caspase-3 protease and caspase-9 protease and inhibiting the damage to mitochondrial membrane potential, as well as mitochondrial cytochrome c. The extract synergistically inhibits apoptotic cardiac cell death by combined administration with the antioxidant, N-acetylcysteine(NAC).
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