Polypeptide and protein derivatives and process for their preparation

摘要

Protein and polypeptide derivatives and their salts are claimed characterized in that a protein or polypeptide is conjugated via an intermediate grouping containing at least one radical of the formula -C(R)=N- (or -N=C(R)-) or -CH(R)-NH- (or -NH-CH(R)-), wherein R is hydrogen or a hydrocarbon residue which may be substituted, with the same or a different protein or polypeptide, with a reporter group or a cytotoxic agent as well as a process for their preparation and the novel intermediates therefor.