| 摘要 |
A novel dipeptide compound inhibiting the enzymatic activity of HIV protease and an anti-AIDS medicine comprising this dipeptide compound as an effective component represented by formula (I)wherein R<1>, R<2>, and R<3 >independently represent C1-4 alkyl, alkoxyl, hydrogen etc . . . (provided that not all of the R<1>, R<2>, and R<3 >are hydrogen), R<2 >and R<3 >may form a ring together, R<4 >represents C1-4 alkyl or hydrogen; X is a methylene group or a sulfur atom; Y represents e.g., a five or six member monocycle or aryloxyalkyl having up to 12 carbon atoms (provided that the aromatic ring may be substituted by alkyl etc . . . ); and Z represents a C1-6 aliphatic hydrocarbon or an aromatic hydrocarbon having up to 12 carbon atoms (provided that this aromatic ring may be substituted by alkyl etc . . . , or at least one carbon atom in the aromatic hydrocarbon may be replaced by a hereto atom).
|
