2,2-DIMETHYL-3-ALKYLETHER-4-ALKOXY-6-ALKYL AMINO BENZOPYRAN DERIVATIVES BY PARALLEL SYNTHESIS ON THE SOLID-PHASE

摘要

PURPOSE: Provided are 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyran derivatives synthesized in higher yield by using parallel synthesis on the solid-phase. The synthesized derivatives inhibit lipid peroxidation. CONSTITUTION: 2,2-dimethyl-3-alkylether-4-alkoxy-6-alkyl amino benzopyran derivatives are characterized by the formula(5), wherein R1 and R2 are the same or different each other, and represent a C1-C10 alkyl group, a benzyl group or a substituted benzyl group, or a penethyl group; and R3 represents a C1-C10 alkyl group, a C2-C10 alkenyl group, a C2-C10 alkynyl group, a benzyl group or a substituted benzyl group, or a naphthylmethyl group; wherein the substituted benzyl group has 1-4 substituents selected from a halogen atom, a nitro group, C1-C10 alkyl group, C1-C10 alkoxy group and C1-C10 haloalkyl group.