ISOQUINUCLIDINE DERIVATIVE, PROCESS FOR PRODUCING THE SAME, AND MEDICINAL COMPOSITION CONTAINING THE SAME

摘要

An isoquinuclidine derivative represented by the following general formula (I): (I) Äwherein A1 is methylene or carbonylÜ: R1 is hydrogen or methyl: R2 is -(CH2)n-A2-Ph (n is an integer of 0 to 3 and A2 is a single bond or -O-): and R3 is -COOH, -COOR4, -COSR4 (R4 is lower alkyl, unsubstituted phenyl, or phenyl substituted by a lower alkyl, lower alkoxy, hydroxyl, methoxycarbonyl, ethoxycarbonyl, or trifluoromethanesulfonamide group or by a halogen atom), etc.Ü or a pharmaceutically acceptable salt of the compound. Also provided is an oral remedy for diabetes, which contains the compound and has hypoglycemic activity. <CHEM>