CARBOXYLIC ACIDS

摘要

The present invention provides a novel carboxylic acid derivative, a salt thereof or a hydrate of them which is useful as an insulin sensitizer, and a medicament comprising the derivative as the effective ingredient. More specifically, it provides a carboxylic acid compound represented by the formula (I), a salt thereof or a hydrate of them. <CHEM> In the formula, Ar represents a 6- to 14-membered aromatic ring group which may have at least one substituent; R<1>, R<2>, R<3>, R<4>, R<5>, R<6>, R<7> and R<8> are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group; X represents an oxygen atom or a methylene group; Y represents a group represented by the formula (II) or (III): <CHEM> (wherein Z represents a group represented by the formula (IV): <CHEM> (wherein R<9>, R<10>, R<11> and R<12> are the same as or different from each other and each represents a hydrogen atom, a halogen atom, a hydroxyl group, a C1-6 alkyl group or a C1-6 alkoxy group)); m is 0 or 1; and n is 0 or 1.