Reagents for lysergic acid diethylamide immunoassay

摘要

The invention provides: lysergic acid diethylamide (LSD) derivatives of formula wherein R<1> and R<2> are independently selected from H or R<3>R<4>; provided that at least one of R<1> and R<2> is H, but both R<1> and R<2> are not simultaneously H; R<3> is a bond or a saturated straight or branched chain hydrocarbon of 1-10 carbon atoms when R<4> is COR<5>, or R<3> is a saturated straight or branched chain hydrocarbon of 1-10 carbon atoms wherein R<4> is NHR<5>; R<5> is selected from H, L or LX; L is a linking group; and X is a detector or carrier molecule bound through L, a reagent for quantitation of lysergic acid and its metabolites in biological fluid samples by an immunoassay, which comprises a label-conjugate of formula I an improved immunoassay for quantitation of LSD and its metabolites in biological fluid samples which utilizes that label-conjugate.