METHOD FOR ALDOL REACTION IN WATER

摘要

A method for aldol reaction in water, which comprises: reacting an aldehyde with a silyl enol ether in an aqueous medium in the presence of a boronic acid represented by the following general formula (1): R<1>R<2>BOH (wherein R<1> and R<2> are the same or different hydrocarbon groups that may contain a substituent), a surfactant, and a Bronsted acid is provided. This method for aldol reaction in water uses a catalytic amount of the boron source to give products in high yield and selectivity.