| 发明名称 |
PROCESS FOR THE PREPARATION OF IMIDAZOLE COMPOUNDS |
| 摘要 |
A process for the preparation of 4-(3-chlorophenyl)-6-[(4-chlorophenyl)hydroxy(1-methyl-1H-imidazol-5-yl)methyl]-1-methyl-2(1H)-quinolinone which comprises reacting 6-(4-chlorobenzoyl)-4-(3-chlorophenyl)-1-methyl-2(1H)-quinolinone with a C6-8alkyllithium compound, 1-methylimidazole and a tri(C4-6alkyl)silyl halide to obtain better yields of the above product. |
| 申请公布号 |
EP1373255(A1) |
申请公布日期 |
2004.01.02 |
| 申请号 |
EP20020722184 |
申请日期 |
2002.03.05 |
| 申请人 |
JANSSEN PHARMACEUTICA N.V. |
发明人 |
FILLIERS, WALTER F.M.;BROECKX, RUDY, L.M.;LEURS, STEFAN, M. H. |
| 分类号 |
A61K31/4709;A61P35/00;C07D401/06;C07D403/06;(IPC1-7):C07D403/06 |
主分类号 |
A61K31/4709 |
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