发明名称 |
Synthetic process for the manufacture of an ecteinaschidin compound |
摘要 |
Processes are provided for preparing compounds with a fused ring structure of formula (XIV). Such products include ecteinascidins and have a spiroamine-1,4-bridge. The process involving forming a 1,4 bridge using a 1-labile, 10-hydroxy, 18-protected hydroxy, di-6,8-en-5-one fused ring compound. After formation of the 1,4 bridge, C-18 protection is removed before spiroamine introduction.
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申请公布号 |
US2004002602(A1) |
申请公布日期 |
2004.01.01 |
申请号 |
US20030257856 |
申请日期 |
2003.03.31 |
申请人 |
FRANCESCH ANDRES;FERNANDEZ CAROLINA;CHICHARRO JOSE LUIS;GALLEGO PILAR;ZARZUELO MARIA;MANZANARES IGNACIO;PEREZ MARTA;CUEVAS CARMEN;MARTIN MARIA JESUS;MUNT SIMON |
发明人 |
FRANCESCH ANDRES;FERNANDEZ CAROLINA;CHICHARRO JOSE LUIS;GALLEGO PILAR;ZARZUELO MARIA;MANZANARES IGNACIO;PEREZ MARTA;CUEVAS CARMEN;MARTIN MARIA JESUS;MUNT SIMON |
分类号 |
C07D471/18;A61K31/4995;A61K35/00;A61P31/04;A61P35/00;C07D;C07D221/00;C07D241/00;C07D291/00;C07D317/00;C07D471/22;C07D487/18;C07D491/22;C07D515/00;C07D515/22;(IPC1-7):C07D225/04 |
主分类号 |
C07D471/18 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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