发明名称 |
Novel 4-dedimethylaminotetracycline derivatives |
摘要 |
The present invention provides new chemically modified 4-dedimethylaminotetracycline compounds that can be substituted with aryl, alkenyl, or alkynyl groups. The 7, 8, and/or 9 positions and methods for preparing such compounds. Other tetracycline compounds include the 4-dedimethylaminotetracycline derivatives with an oxime group, NH-Alkyl, or N-NH-Alkyl group substituted at the C4 position as well as C2 Mannich derivatives. The present invention also provides a method of treating a mammal suffering from conditions or diseases by administering to the mammal an effective amount of the new chemically modified tetracycline compounds.
|
申请公布号 |
US2004002481(A1) |
申请公布日期 |
2004.01.01 |
申请号 |
US20030458076 |
申请日期 |
2003.06.10 |
申请人 |
COLLAGENEX PHARMACEUTICALS, INC. |
发明人 |
ASHLEY ROBERT;HLAVKA JOSEPH J. |
分类号 |
C07D295/12;A61K31/65;A61P1/02;A61P1/04;A61P1/18;A61P3/10;A61P7/00;A61P7/04;A61P9/14;A61P11/00;A61P13/12;A61P17/00;A61P17/06;A61P19/00;A61P19/02;A61P19/10;A61P27/02;A61P29/00;A61P31/04;A61P35/00;A61P37/02;A61P37/06;A61P43/00;C07C235/82;C07C237/26;C07C245/20;C07C247/18;C07C329/20;C07D295/13;(IPC1-7):A61K31/65 |
主分类号 |
C07D295/12 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|