发明名称 |
POLYMORPHS OF A CRYSTALLINE AZABICYCLO (2,2,2) OCTAN-3-AMINE CITRATE AND THEIR PHARMACEUTICAL COMPOSITIONS |
摘要 |
<p>A single crystalline polymorphic form (2S,3S)-N-(methoxy-5-t-butylphenylmethyl-2-diphenylmethyl-1-azobicyclo[2,2,2] octan-3-amine citrate(citrate monohydrate) and its pharmaceutical composition. The pharmaceutical composition of the polymorphic form if the citrate monohydrate has advantageous stability for formulation to treat emesis. The administration of this pharmaceutical composition is immediate release, oral dosage form preferably by tablet or capsule or intravenous.</p> |
申请公布号 |
SI1181290(T1) |
申请公布日期 |
2003.12.31 |
申请号 |
SI20000030161T |
申请日期 |
2000.05.18 |
申请人 |
PFIZER PRODUCTS INC. |
发明人 |
CASTALDI MICHAEL JAMES;QUALLICH GEORGE JOSEPH;WINT LEWIN THEOPHILUS |
分类号 |
A61K31/439;A61P1/08;C07D453/02;(IPC1-7):C07D453/02 |
主分类号 |
A61K31/439 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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