CLINICAL GRADE VECTORS BASED ON NATURAL MICROFLORA FOR USE IN DELIVERING THERAPEUTIC COMPOSITIONS

摘要

Clinical grade vectors comprising transformed microflora vector having at least one transforming nucleic acid sequence containing at least one gene of interest are provided. The transforming nucleic acid encodes for a therapeutic polypeptide that is delivered to the host in need thereof topically, orally, intranasally and/or transderamally. The clinical grade vectors are derived from lactic acid bacteria, yeast and other non-pathogenic microorganisms and have been provided with selective/and or reporter genes that do not rely on antibiotic resistance. Moreover, the clinical grade vectors are provided with phenotypic and/or genotypic traits that limit the ex vivo dissemination of transforming nucleic acid sequence(s). Also provided are methods and compositions useful in treating diseases in animals.