| 发明名称 |
NEW USE OF PYRIMIDINE - OR TRIAZINE- 2-CARBONITILES FOR TREATING DISEASES ASSOCIATED WITH CYSTEINE PROTEASE ACTIVITY AND NOVEL PYRIMIDINE-2-CARBONITILE DERIVATIVES |
| 摘要 |
<p>The present invention therefore provides use of a compound of formula (I) and compositions for treating diseases associated with cysteine protease activity. The compounds are reversible inhibitors of cysteine proteases S, K, F, L and B. Of particular interest are diseases associated with Cathepsin S. In addition, this invention also discloses processes for the preparation of such inhibitors.</p> |
| 申请公布号 |
WO2004000819(A1) |
申请公布日期 |
2003.12.31 |
| 申请号 |
WO2003SE01078 |
申请日期 |
2003.06.23 |
| 申请人 |
ASTRAZENECA AB;BAILEY, ANDREW;PAIRAUDEAU, GARRY;PATEL, ANIL;THOM, STEPHEN |
发明人 |
BAILEY, ANDREW;PAIRAUDEAU, GARRY;PATEL, ANIL;THOM, STEPHEN |
| 分类号 |
A61K31/506;A61K31/53;A61K31/5377;A61P9/00;A61P11/00;A61P11/06;A61P19/02;A61P19/10;A61P25/00;A61P25/28;A61P29/00;A61P37/00;A61P43/00;C07D239/46;C07D239/48;C07D239/50;C07D251/18;C07D401/04;C07D401/12;C07D401/14;C07D403/04;C07D403/12;C07D405/04;C07D405/12;C07D413/14;C07D487/08;(IPC1-7):C07D239/24;C07D251/14;C07D405/06;C07D403/06;C07D401/06 |
主分类号 |
A61K31/506 |
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