INHIBITION OF NUCLEAR RECEPTORS

摘要

The present invention relates to a method of inhibiting expression of a nuclear receptor gene in a mammalian cell or tissue by introduction of a sense strand and corresponding antisense strand RNA sequence of about 21 to about 23 nucleotides complementary to a part of the receptor mRNA into such cell or tissue, to the 21 - 23 nt nucleotides themselves and corresponding transfer systems and their uses in the preparation of pharmaceutical compositions useful in the treatment of diseases caused by altered expression of the nuclear receptor gene. The invention also relates to a method of examining the function of a mammalian nuclear receptor gene in a cell or tissue.