发明名称 |
RANDOMISED DNA LIBRARIES AND DOUBLE-STRANDED RNA LIBRARIES, USE AND METHOD OF PRODUCTION THEREOF |
摘要 |
<p>This invention relates to DNA libraries based on plasmid or viral vectors that can express double-stranded RNA of 10-30 base pairs in length with all possible sequences, where each of the double stranded RNA is formed by a single RNA molecule in the form of hairpin, or formed by two separate RNA molecules with different 3'-overhangs. Each single member in such a DNA library encodes all components of a double stranded RNA as specified above. Such a library can be used in screening for double stranded RNA species that can induce a given phenotype without prior knowledge of their target genes. This invention further relates to a method to generate such a DNA library.</p> |
申请公布号 |
WO2004001044(A1) |
申请公布日期 |
2003.12.31 |
申请号 |
WO2003SE01077 |
申请日期 |
2003.06.23 |
申请人 |
SINOGENOMAX COMPANY LTD.;LIANG, ZICAI;ZHANG, HONG-YAN;CHEN, MEIHONG;SHEN, YAN |
发明人 |
LIANG, ZICAI;ZHANG, HONG-YAN;CHEN, MEIHONG;SHEN, YAN |
分类号 |
C12N15/09;C12N15/10;C12N15/11;C12Q1/68;(IPC1-7):C12N15/10;C12N15/63 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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