摘要 |
The present invention provides nucleoside compounds and certain derivatives thereof which are inhibitors of RNA-dependent RNA viral polymerase. These compounds are inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as inhibitors of hepatitis C virus (HCV) NS5B polymerase, as inhibitors of HCV replication, and/or for the treatment of hepatitis C infection. The invention also describes pharmaceutical compositions containing such nucleoside compounds alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclosed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-dependent RNA viral replication, and/or treating RNA-dependent RNA viral infection with the nucleoside compounds of the present invention. |
申请人 |
MERCK & CO., INC.;ISIS PHARMACEUTICALS, INC.;CARROLL, STEVEN, S.;OLSEN, DAVID, B.;DURETTE, PHILIPPE, L.;BHAT, BALKRISHEN;DANDE, PRASAD;ELDRUP, ANNE, B. |
发明人 |
CARROLL, STEVEN, S.;OLSEN, DAVID, B.;DURETTE, PHILIPPE, L.;BHAT, BALKRISHEN;DANDE, PRASAD;ELDRUP, ANNE, B. |