发明名称 |
ARYLAMINE SUBSTITUTED BICYCLIC HETEROAROMATIC COMPOUNDS AS P38 KINASE INHIBITORS |
摘要 |
Bicyclic heteroaromatic derivatives of formula (1) are described: F (1) wher e: the dashed line joining A and C(Ra) is present and represents a bond and A i s a -N= atom or a -C(Rb)= group, or the dashed line is absent and A is a -N(Rb )- , or -C(Rb)(Rc)- group; X is an -O-, -S- or substituted nitrogen atom or a - S(O)-, -S(O2)- or -NH~-group; Y is a nitrogen or substituted carbon atom or a - CH= group; n is zero or the integer 1; Alk1 is an optionally substituted aliphatic or heteroaliphatic chain L1 is a covalent bond or a linker atom or group; Cy1 is a hydrogen atom or an optionally substituted cycloaliphatic, polycycloaliphatic, heterocycloaliphatic, polyheterocycloaliphatic, aromatic or heteroaromatic group; Ar is an optionally substituted aromatic or heteroaromatic group; and the remaining substituents are defined in the specification. The compounds are potent and selective inhibitors of p38 kina se and are of use in the prophylaxis and treatment of immune or inflammatory disorders.
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申请公布号 |
CA2487718(A1) |
申请公布日期 |
2003.12.31 |
申请号 |
CA20032487718 |
申请日期 |
2003.06.20 |
申请人 |
CELLTECH R & D LIMITED |
发明人 |
BROOKINGS, DANIEL CHRISTOPHER;DAVIS, JEREMY MARTIN;LANGHAM, BARRY JOHN |
分类号 |
A61K31/4743;A61P1/04;A61P1/16;A61P3/10;A61P7/00;A61P7/02;A61P7/04;A61P7/06;A61P9/10;A61P11/00;A61P11/06;A61P13/12;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P19/08;A61P19/10;A61P21/04;A61P25/00;A61P25/16;A61P25/28;A61P29/00;A61P31/00;A61P31/12;A61P31/16;A61P31/22;A61P35/00;A61P35/02;A61P37/00;A61P37/02;A61P37/08;A61P43/00;C07D495/04;(IPC1-7):C07D495/04;A61K31/44 |
主分类号 |
A61K31/4743 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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