PHARMACEUTICAL COMPOSITION WITH STABILISED AMORPHOUS DONEPEZIL,CHLORIDE

摘要

The present invention relates to stabilised pharmaceutical composition amorphous form of 1-benzyl-4-((5,6-dimethoxy-1-indanon)-2-yl)methyl-piperidine (donepezil) hydrochloride and a process for its stabilization. Pharmaceutical composition is prepared by in situ formation of donepezil chloride and loading of the obtained solution onto a mixture of pharmaceutically acceptable excipients. Amorphous form is stabilized by addition of crystallization inhibitor to the solution or to the mixture of pharmaceutically acceptable excipients.