发明名称 |
AN INVERTEBRATE ANIMAL MODEL WITH NEURODEGENERATIVE PHENOTYPE FOR SCREENING AND TESTING SUBSTANCES |
摘要 |
The present invention claims an invertebrate animal that has been modified to express a set of genes, said set comprising the gene coding for a modified version of the gamma subunit of AMP-activated protein kinase (AMPKg). According to the invention, the animal displays an identifiable phenotype related to lipid metabolism and neurodegeneration. This animal provides a model of neurodegenerative diseases, particularly Alzheimer's disease, and may be useful for screening and testing modulating agents, substances and therapeutic compounds for neurodegenerative disorders. |
申请公布号 |
WO03065795(A3) |
申请公布日期 |
2003.12.31 |
申请号 |
WO2002EP03992 |
申请日期 |
2002.04.10 |
申请人 |
EVOTEC NEUROSCIENCES GMBH;KRETZSCHMAR, DORIS;TSCHAEPE, JAKOB-ANDREAS |
发明人 |
KRETZSCHMAR, DORIS;TSCHAEPE, JAKOB-ANDREAS |
分类号 |
A01K;A01K67/033;C07K14/435;C07K14/47;C12N9/12;C12N15/85;C12Q1/68;G01N33/50 |
主分类号 |
A01K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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