SUSTAINED-RELEASE COMPOSITION, PROCESS FOR PRODUCING THE SAME AND PREPARATION THEREOF

摘要

A sustained-release composition capable of exerting sustained-release effects for a prolonged period of time by injection of fine particles thereof in an amount causing no pain, the injection easily performed, for example, under the human skin or intramuscularly. The sustained-release composition is obtained by filling pores of porous hydroxyapatite fine particles with a biologically active drug, a human serum protein and mucopolysaccharide and obturating the filled particles by adding a divalent metal ion. Also, the sustained-release composition is obtained by filling pores of porous hydroxyapatite fine particles with a biologically active drug, a human serum protein and a water-soluble calcium salt in sequence or simultaneously and obturating the outer layer of the fine particles by adding sodium carbonate or sodium hydrogen carbonate or an aqueous carbonate ion solution.