| 发明名称 |
Delivery of therapeutic agents by gene therapy |
| 摘要 |
A process for treating a disease or disorder of a host by delivery of a therapeutic agent to the brain of the host, which comprises transducing endothelial cells of blood vessels located in the brain of a host in vivo with a vector including a polynucleotide encoding a therapeutic agent. The vector is administered intravascularly to the host, and the vector produces the therapeutic agent in the endothelial cells.
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| 申请公布号 |
US6669935(B1) |
申请公布日期 |
2003.12.30 |
| 申请号 |
US19980212165 |
申请日期 |
1998.12.15 |
| 申请人 |
THE UNITED STATES OF AMERICA AS REPRESENTED BY THE DEPARTMENT OF HEALTH AND HUMAN SERVICES;GENETIC THERAPY, INC. |
发明人 |
OLDFIELD EDWARD H.;RAM ZVI;MCGARRITY GERARD J. |
| 分类号 |
A61K38/46;A61K31/52;A61K31/70;A61K35/76;A61K38/45;A61K38/50;A61K48/00;A61P35/00;C12N15/861;C12N15/90;(IPC1-7):A01N63/00;C12N15/63;C12N15/86 |
主分类号 |
A61K38/46 |
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