| 摘要 |
Compounds of formula IwhereinR1 is for example 3-methoxyprop-3-yloxy, R2 is for example methoxy, R3 and R4 are in each case for example isopropyl, and R5 is H2NC(O)-[C(CH3)2]-CH2-, are obtainable by reaction of compounds of formula IVwith a metal organic derivative of 1-(3-R1-4-R2-phen-1-yl)-2-R3-3-halogen propanes to form a compound of formula VI,followed by removal of the pseudoephedrine protecting group and the OH group, reaction of the resulting lactone with an amine R5-NH2 and removal of protecting group Z.
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