发明名称 |
ORAL PHARMACEUTICAL FORMS OF ADMINISTRATION WITH A DELAYED ACTION |
摘要 |
A partially delayed oral pharmaceutical dosage form (A) comprising tramadol (I) as active agent, (I) is at least partially in the form of a compound (I') formed in situ and having at water solubility of 50 mg/ml or less (especially 5 mg/ml or less). An independent claim is included for the preparation of (A), by mixing tramadol (I) with an acidic drug or auxiliary (II) (or its water-soluble salt) and optionally auxiliaries, wetting and formulating with application of energy. |
申请公布号 |
PL354239(A1) |
申请公布日期 |
2003.12.29 |
申请号 |
PL20000354239 |
申请日期 |
2000.08.03 |
申请人 |
GRUNENTHAL GMBH |
发明人 |
ZIEGLER IRIS;BARTHOLOMAUS JOHANNES |
分类号 |
A61K9/16;A61K9/20;A61K9/22;A61K9/28;A61K9/30;A61K9/50;A61K9/52;A61K31/135;A61K31/19;A61K31/192;A61K31/195;A61K31/196;A61K31/428;A61K31/60;A61K31/616;A61K47/12;A61K47/20;A61K47/22;A61P1/04;A61P1/12;A61P9/00;A61P11/00;A61P11/14;A61P13/00;A61P13/02;A61P25/00;A61P25/08;A61P25/18;A61P25/24;A61P25/30;A61P25/32;A61P25/36;A61P29/00;A61P37/08 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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