| 摘要 |
The present invention relates to OTB182, and all facets of novel polynucleotides encoded by it, the polypeptides they encode, antibodies and specific binding partners thereto, and their applications to research, diagnosis, drug discovery, therapy, clinical medicine, forensic science and medicine, etc. The polynucleotides are expressed in excitable tissues, such as heart, brain, and muscle, and are therefore useful in variety of ways, including, but not limited to, as molecular markers, as drug targets, and for detecting, diagnosing, staging, monitoring, prognosticating, preventing or treating, determining predisposition to, etc., diseases and conditions, such neuropathy, neuralgic amyotrophy (e.g., HNA), myopathy, sensorineural hearing loss (e.g., DFNA20), mental retardation, neuromuscular disorders, and other diseases especially relating to excitable tissues, such as heart, brain, and muscle.
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