发明名称 |
Systems and methods for predicting oligonucleotide melting temperature (TmS) |
摘要 |
Software systems and methods for predicting the melting temperature (Tm) and other characteristics of oligonucleotides, including modified oligonucleotides. Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
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申请公布号 |
US2003235822(A1) |
申请公布日期 |
2003.12.25 |
申请号 |
US20020176972 |
申请日期 |
2002.06.18 |
申请人 |
EPOCH BIOSCIENCES, INC. |
发明人 |
LOKHOV SERGEY G.;KUTYAVIN IGOR V.;DEMPCY ROBERT O.;GALL ALEXANDER A.;AFONINA IRINA A.;SINGER MICHAEL J.;VERMEULEN NICOLAAS M.J. |
分类号 |
C12N15/09;C07B61/00;C07H19/06;C07H19/10;C07H19/16;C07H19/20;C07H19/23;C07H21/00;C12Q1/68;G06F17/00;G06F19/20;G06F19/22;(IPC1-7):C12Q1/68;G06F19/00;G01N33/48;G01N33/50 |
主分类号 |
C12N15/09 |
代理机构 |
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