PRESSURIZED METERED DOSE INHALERS

摘要

1. Pressurized metered dose inhalers containing a solution of an active ingredient in a hydrofluorocarbon propellant, a co-solvent and optionally a low-volatility component characterized in that part or all of the internal surfaces of said inhalers consist of stainless steel, anodized aluminium or are lined with an inert organic coating, selected from perfluoroalkoxyalkane, epoxy-phenol resin or fluorinated-ethylene-propylene polyether sulfone, said material preventing the chemical degradation of the active ingredient with proviso that if active ingredient is fluonizonide, inert coating is not epoxy l resin. 2. Pressurized metered dose inhalers according to claim 1, characterized in that the active ingredients are selected from beta2 agonists, steroids or anti-cholinergic agents and their combinations, with proviso that if active ingredient comprises fluonizonide, inert coating is not epoxy resin. 3. Pressurized metered dose inhalers according to claim 2, characterized in that the active ingredient is ipratropium bromide, oxitropium bromide, tiotropium bromide, flunisolide, triamcinolone acetonide, fluticasone propionate, mometasone furoate, budesonide, ciclesonide, rofleponide and epimers thereof. 4. Pressurized metered dose inhalers according to any of claims from 1 to 3, characterized by containing a lowvolatility component selected from glycerol, polyethylene glycol and isopropyl myristate. 5. Pressurized metered dose inhalers according to any of claims from 1 to 4, characterized in that the co-solvent is ethanol. 6. Pressurized metered dose inhalers according to any of claims from 1 to 5, characterized in that the propellant is selected from HFA 227, HFA 134a and their mixtures. 7. Pressurized metered dose inhalers according to any of claims 1 to 7, characterized in that part or all of the internal surfaces are coated with an epoxy phenol resin. 8. Pressurized metered dose inhalers according to any of claims 1 to 6, characterized in that part or all of the internal surfaces consist of anodized aluminium. 9. Pressurized metered dose inhalers according to any of claims 1 to 8, characterized in that the active ingredient is budesonide or dex-budesonide, and co-solvent is ethanol.