PROCESS FOR THE PREPARATION OF OXAZOLIDINONES AND METHOD OF USE THEREOF

摘要

A process for preparing N-(substituted)-C~- (substituted methyl)- oxazolidinones, C-(substituted methyl)-oxazolidinones, and N-(substituted)-C ~- (substituted ethyl)-oxazolidinones, preferably chiral, from optically active C- (protected oxymethyl)~ oxazolidinones is described. The process can be used to produce combinatorial libraries of the above substituted oxazolidinones in a two or three step reaction comprising a plurality of reagents differing in numbers of carbons or particular substituted oxazolidinones. A number of substituted oxazolidinones produced using the above process have been discovered to have antimicrobial activity.