发明名称 |
PEPTIDES SELECTIVELY LETHAL TO MALIGNANT AND TRANSFORMED MAMMALIAN CELLS |
摘要 |
The present invention provides peptides corresponding to all or a portion of amino acid residues 12-26 of human p53 protein, which peptides are lethal to malignant or tranformed cells when fused to a membrane-penetrating leader sequence. The subject peptides are thus useful in treating neoplastic diseas e in an animal, preferably a human. Also provided are pharmaceutical compositions comprising the subject peptides admixed with a pharmaceutical acceptable carrier. Methods of treating neoplastic disease in a patient by administering a subject peptide fused at its carboxy terminal end to a membrane-penetrating leader sequence are also provided.
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申请公布号 |
CA2477878(A1) |
申请公布日期 |
2003.12.24 |
申请号 |
CA20032477878 |
申请日期 |
2003.03.12 |
申请人 |
THE RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK |
发明人 |
PINCUS, MATTHEW R. |
分类号 |
A61K38/00;A61K38/10;A61K38/17;A61K47/48;A61P35/00;A61P43/00;C07K7/06;C07K7/08;C07K14/47;(IPC1-7):C07K19/00;A61K38/16 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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