SYSTEMS AND METHODS FOR PREDICTING OLIGONUCLEOTIDE MELTING TEMPERATURES (TMS)
摘要
Software systems and methods for predicting the melting temperature (Tm) and other characteristics of oligonucleotides, including modified oligonucleotides. Modified oligonucleotides are provided containing bases selected from unsubstituted and 3-substituted pyrazolo[3,4-d]pyrimidines and 5-substituted pyrimidines, and optionally have attached minor groove binders and reporter groups.
申请公布号
WO03107144(A2)
申请公布日期
2003.12.24
申请号
WO2003US19447
申请日期
2003.06.18
申请人
EPOCH BIOSCIENCES, INC.
发明人
DEMPCY, ROBERT, O.;GALL, ALEXANDER, A.;LOKHOV, SERGEY, G.;AFONINA, IRINA, A.;SINGER, MICHAEL, J.;KUTYAVIN, IGOR, V.;VERMEULEN, NICOLAAS, M., J.