| 摘要 |
The present invention relates to a novel parenteral composition comprising propofol and electrokinetic stabilizer. The electrokinetic stabilizer maintains the zeta potential of the propofol injection at a higher value than the critical zeta potential as absolute value. The electrokinetic stabilizer is pharmaceutically acceptable and injectable. It is selected from the group consisting of a basic amino acid such as lysine, arginine, or histidine; a basic compound or a salt such as monoethanolamine, diethanolamine, sodium carbonate, sodium bicarbonate, tromethamine, or sodium phosphate; or a mixture thereof. Even though a large amount of lidocaine is admixed to the propofol injection of this invention to reduce the pain on injection of propofol, or a relatively long time elapses after admixing, the propofol composition of this invention maintained physicochemical stability and thus can be used as a painless, effective, and safe intravenous anesthetic without adverse effects like pulmonary embolism. |
