| 摘要 |
This invention provides compounds that are antagonists of melanin concentrating hormone receptor-1 (MCH-R1). The compounds are represented by formula (I): where m is zero or one, n is zero to two, Y is oxygen or -N (R<9>)-, R<1>, R<2>, R<3>, R<4>, R<5>, R<9>, and Ring A are defined in the specification. Coumarin and quinolone compounds where R<1> and R<2> together form a fused benzo ring are preferred. The invention also provides compounds of formula (VI) where the coumarin moiety is replaced by a quinazolinone ring. The compounds are useful for treating MCH-R1-related disorders, particularly overweight conditions including obesity. |
| 申请人 |
MILLENNIUM PHARMACEUTICALS, INC.;BLACKBURN, CHRISTOPHER;LAI, SU-JEN;LEE, JENNIFER, G.;MAGUIRE, MARTIN;PATANE, MICHAEL, A.;LAMARCHE, MATTHEW, J.;CULLIS, COURTNEY, A.;BROWN, JAMES;VASUDEVAN, ANIL;FREEMAN, JENNIFER, C.;MULHERN, MATHEW, M.;LYNCH, JOHN, K.;GAO, JU;WODKA, DARIUSZ;SOUERS, ANDREW, J.;IYENGAR, RAJESH |
发明人 |
BLACKBURN, CHRISTOPHER;LAI, SU-JEN;LEE, JENNIFER, G.;MAGUIRE, MARTIN;PATANE, MICHAEL, A.;LAMARCHE, MATTHEW, J.;CULLIS, COURTNEY, A.;BROWN, JAMES;VASUDEVAN, ANIL;FREEMAN, JENNIFER, C.;MULHERN, MATHEW, M.;LYNCH, JOHN, K.;GAO, JU;WODKA, DARIUSZ;SOUERS, ANDREW, J.;IYENGAR, RAJESH |
