摘要 |
Compounds having the formula (I), are useful as inhibitors of mitochondrial F>10< ATP hydrolase, wherein R?1#191, R>5< AND R>7< are optional substituents, R>2<, R>3< AND R>4< are hydrogen, alkyl, or substituted alkyl, or comprise a bond to R, T or Y; Z and Y are selected from C(=O), -CO>2<-, -SO>2<-, -CH>2<-, -CH>2<C(=O)-, and -C(=O)C(=O)-, or Z may be absent; R and T are CH>2<-, -C(=O)-, or -CH[(CH>2<)>p<(Q)]-, WHEREIN Q IS NR>10<R>11<, OR>10< OR CN ANDp is 0, 1 or 2; R>6< is alkyl, alkenyl, substituted alkyl, substituted alkenyl, aryl, cycloalkyl, heterocyclo, or heteroaryl; R>10< AND R>11< are hydrogen, alkyl, or substituted alkyl; and r and t are 0 or 1. |
申请人 |
BRISTOL-MYERS SQUIBB COMPANY;DING, CHARLES, Z.;HAMANN, LAWRENCE, G.;STEIN, PHILIP, D.;PUDZIANOWSKI, ANDREW, T. |
发明人 |
DING, CHARLES, Z.;HAMANN, LAWRENCE, G.;STEIN, PHILIP, D.;PUDZIANOWSKI, ANDREW, T. |