发明名称 |
METHODS AND COMPOSITIONS FOR THE IDENTIFICATION, ASSESSMENT, AND THERAPY OF SMALL CELL LUNG CANCER |
摘要 |
The invention provides novel methods and compositions for modulating small cell lung cancer (SCLC) proliferation and metastasis through modulation of CXCR4 activity or expression. Also provided are methods for identifying compounds that modulate SCLC proliferation and metastasis through modulation of CXCR4 activity or expression. Further provided are methods for treating SCLC proliferation and metastasis, as well as methods for determining whether subjects are suitable candidates for treatment of SCLC via modulation of CXCR4 activity. |
申请公布号 |
WO03079020(A3) |
申请公布日期 |
2003.12.24 |
申请号 |
WO2003EP02916 |
申请日期 |
2003.03.20 |
申请人 |
DANA-FARBER CANCER INSTITUTE INC.;NOVARTIS AG;SALGIA, RAVI |
发明人 |
SALGIA, RAVI |
分类号 |
A61K31/00;A61K31/7088;A61K38/00;A61K38/54;A61K39/395;A61K45/00;A61K48/00;A61P35/00;A61P35/04;A61P43/00;C12N15/09;C12Q1/02;G01N33/15;G01N33/50;G01N33/574 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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