| 发明名称 |
ASPARTYL PROTEASE INHIBITORS |
| 摘要 |
The present invention provides compounds having formula (I): wherein R', R<0>, R<1>, X<1>, R<2>, R<3>, R<3>', X<2>, X<3>, and R4 are as defined herein, and pharmaceuticals compositions thereof. The present invention also provides methods of inhibiting proteases, more specially aspartyl proteases. In certain embodiments, compounds inhibit BACE (beta-site APP-cleaving enzyme), and thus are useful in the treatment or prevention of a disease characterized by beta-amyloid deposits in the brain (including, but not limited to, Alzheimer's Disease). The present invention also provides methods for preparing compounds of the invention.
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| 申请公布号 |
WO03106405(A1) |
申请公布日期 |
2003.12.24 |
| 申请号 |
WO2003US18858 |
申请日期 |
2003.06.16 |
| 申请人 |
SUNESIS PHARMACEUTICALS, INC.;YANG, WENJIN;CARY, DOUGLAS, R.;JACOBS, JEFFREY, W.;LU, WANLI;LU, YAFAN;SUN, JIAN;ZHONG, MIN |
发明人 |
YANG, WENJIN;CARY, DOUGLAS, R.;JACOBS, JEFFREY, W.;LU, WANLI;LU, YAFAN;SUN, JIAN;ZHONG, MIN |
| 分类号 |
C12N9/99;A61K31/166;A61K31/167;A61K38/00;A61P25/28;C07C231/12;C07C233/78;C07C235/50;C07C237/22;C07C271/54;C07C303/40;C07C311/08;C07C311/16;C07C311/21;C07C311/37;C07D207/08;C07D213/81;C07D213/82;C07D217/14;C07D241/08;C07D249/08;C07D263/32;C07D275/02;C07D277/30;C07D285/06;C07D285/10;C07D285/16;C07D285/18;C07D295/192;C07D307/54;C07D333/24;C07D333/38;C07D401/06;C07D409/06;C07K1/08;C07K5/027;C07K5/03;(IPC1-7):C07C237/22;C07C237/12;C07C237/14;C07D333/02;C07D307/02;C07D277/02;C07D263/02;C07D211/04;C07D209/02 |
主分类号 |
C12N9/99 |
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