| 摘要 |
PURPOSE: A pharmaceutical composition comprising benzoindole carboxylic acid derivatives is provided, which inhibits the activity of protein tyrosine phosphatase 1B(PTP1B) effectively, and is thus useful as a PTP1B inhibitor, or for prevention and treatment of obesity or diabetes. CONSTITUTION: A pharmaceutical composition for inhibiting the activity of protein tyrosine phosphatase 1B(PTP1B) is characterized by containing a compound represented by the formula(1), or its pharmaceutically acceptable slats, hydrates, solvates or isomers. In the formula(1), R is a halogen, alkyloxy, alkyl, amino, alkyl amino, carboxylic acid or amide substituted or unsubstituted aromatic group, or a nitrogen, sulfur or oxygen-containing heterocyclic aromatic group.
|
